The DnD game Kendra is talking about starts with this comic. Way back in 2010!

↓ Transcript
Panel 1:
Same as panel three in previous comic.
Lisa: Hi Kendra! How was your weekend?
Kendra (walking past): Oh...good.
Panel 2:
But unlike last comic, we follow Kendra.
Kendra (to herself): It wasn't good. Ever since I stopped playing WoW altogether I don't have friends to hang out with regularly. And Lisa and Mike didn't keep that D&D game going.
Panel 3:
Kendra (to herself): I wish I was better at maintaining friendships. People keep moving on.
Panel 4:
Kendra (to herself): *sob* Like my Animal Crossing villagers.